Ex vivo fucosylation of third-party human regulatory T cells enhances anti-graft-versus-host disease potency in vivo.

@article{Parmar2015ExVF,
  title={Ex vivo fucosylation of third-party human regulatory T cells enhances anti-graft-versus-host disease potency in vivo.},
  author={Simrit Parmar and Xiaoying Liu and Amer M. Najjar and Nina B Shah and Hong Yang and Eric S Yvon and Katy Rezvani and I K Mcniece and Patrick A. Zweidler-McKay and Leonard Miller and Steve Wolpe and Bruce R Blazar and Elizabeth J Shpall},
  journal={Blood},
  year={2015},
  volume={125 9},
  pages={1502-6}
}
Adoptive therapy with regulatory T cells (Tregs) to prevent graft-versus-host disease (GVHD) would benefit from a strategy to improve homing to the sites of inflammation. We hypothesized that adding fucose to human Tregs, forming the Sialyl Lewis X moiety on P-selectin glycoprotein ligand-1, would improve their trafficking pattern. The selectin pathway recruiter, α-1,3-fucosyltransferase-VI enzyme, significantly increased Treg surface fucosylation (66% vs 8%). In a xenogenic GVHD mouse model… CONTINUE READING
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