Ex vivo expansion protocol for human tumor specific T cells for adoptive T cell therapy.

@article{Rasmussen2010ExVE,
  title={Ex vivo expansion protocol for human tumor specific T cells for adoptive T cell therapy.},
  author={Anne-Marie Rasmussen and Gabriel Borelli and Hanna Julie Hoel and Kari Lislerud and Gustav Gaudernack and Gunnar Kvalheim and Tanja Aarvak},
  journal={Journal of immunological methods},
  year={2010},
  volume={355 1-2},
  pages={52-60}
}
Adoptive T cell therapy is a promising treatment strategy for patients with different types of cancer. The methods used for generation of high numbers of tumor specific T cells usually require long-term ex vivo culture, which frequently lead to generation of terminally differentiated effector cells, demonstrating low persistence in vivo. Therefore, optimization of protocols for generation of T cells for adoptive cell therapy is warranted. The aim of this work was to develop a protocol for… CONTINUE READING
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