Ex vivo expansion of umbilical cord blood stem cells for transplantation: growing knowledge from the hematopoietic niche

@article{Hofmeister2007ExVE,
  title={Ex vivo expansion of umbilical cord blood stem cells for transplantation: growing knowledge from the hematopoietic niche},
  author={Craig C Hofmeister and Junyan Zhang and Katherine L. Knight and Phuong Le and Patrick Stiff},
  journal={Bone Marrow Transplantation},
  year={2007},
  volume={39},
  pages={11-23}
}
Umbilical cord blood transplantation (UCBT) in adults is limited by the small number of primitive hematopoietic stem cells (HSC) in each graft, resulting in delayed engraftment post transplant, and both short- and long-term infectious complications. Initial efforts to expand UCB progenitors ex vivo have resulted in expansion of mature rather than immature HSC, confounded by the inability to accurately and reliably measure long-term reconstituting cells. Ex vivo expansion of UCB HSC has failed… CONTINUE READING
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Optimization of expansion of cord blood T cells with anti-CD3/anti-CD28 coated beads

  • AG Rieber, S Parmar, SN Robinson, W Decker, D Xing, KV Komanduri
  • Biol Blood Marrow Transplant
  • 2006

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