Ex vivo expansion of rat bone marrow mesenchymal stromal cells on microcarrier beads in spin culture.

@article{Yang2007ExVE,
  title={Ex vivo expansion of rat bone marrow mesenchymal stromal cells on microcarrier beads in spin culture.},
  author={Yi Yang and Fabio M V Rossi and Edward E Putnins},
  journal={Biomaterials},
  year={2007},
  volume={28 20},
  pages={
          3110-20
        }
}
Bone marrow mesenchymal stromal cells (BM-MSC) are attractive candidates for connective tissue regeneration. Currently, their use is limited by poor overall cell survival and high apoptosis rates upon transplantation in vivo. We hypothesized that disruption of cell-extracellular matrix contact either during cell expansion or immediately prior to cell transplantation may impair cell viability and facilitate apoptosis. We therefore investigated whether BM-MSC can be expanded on microcarrier beads… CONTINUE READING

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