Ex vivo expansion of human adult stem cells capable of primary and secondary hemopoietic reconstitution.

@article{Gammaitoni2003ExVE,
  title={Ex vivo expansion of human adult stem cells capable of primary and secondary hemopoietic reconstitution.},
  author={Loretta Gammaitoni and Stefania Bruno and Fiorella Sanavio and Monica Gunetti and Orit Kollet and Giuliana Cavalloni and Michele Falda and Franca Fagioli and Tsvee Lapidot and Massimo Aglietta and Wanda Piacibello},
  journal={Experimental hematology},
  year={2003},
  volume={31 3},
  pages={261-70}
}
OBJECTIVE Ex vivo expansion of human hemopoietic stem cells (HSC) is an important issue in transplantation and gene therapy. Encouraging results have been obtained with cord blood, where extensive amplification of primitive progenitors was observed. So far, this goal has been elusive with adult cells, in which amplification of committed and mature cells, but not of long-term repopulating cells, has been described. METHODS Adult normal bone marrow (BM) and mobilized peripheral blood (MPB) CD34… CONTINUE READING

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