Ex vivo expansion of CD4(+)CD25(+) T regulatory cells for immunosuppressive therapy.

@article{Trzonkowski2009ExVE,
  title={Ex vivo expansion of CD4(+)CD25(+) T regulatory cells for immunosuppressive therapy.},
  author={Piotr Trzonkowski and Magdalena Szaryńska and Jolanta M. Myśliwska and Andrzej Myśliwski},
  journal={Cytometry. Part A : the journal of the International Society for Analytical Cytology},
  year={2009},
  volume={75 3},
  pages={175-88}
}
Immunosuppressants are powerful drugs, capable of triggering severe adverse effects. Hence, there is tremendous interest in replacing them with less-toxic agents. Adoptive therapy with CD25(+)CD4(+) T regulatory cells (Tregs) holds promise as an alternative to immunosuppressants. Tregs have been described as the most potent immunosuppressive cells in the human body. In a number of experimental models, they have been found to quench autoimmune diseases, maintain allogeneic transplants, and… CONTINUE READING
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