Ex vivo-expanded cynomolgus macaque regulatory T cells are resistant to alemtuzumab-mediated cytotoxicity.

@article{Dons2013ExVC,
  title={Ex vivo-expanded cynomolgus macaque regulatory T cells are resistant to alemtuzumab-mediated cytotoxicity.},
  author={Eefje M. Dons and Giorgio Raimondi and Haojiang Zhang and Alan F. Zahorchak and Jay Kumar Bhama and Lien Lu and Mohamed B Ezzelarab and Jan Nicolaas Maria Ijzermans and David Cronin Cooper and Angus W Thomson},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2013},
  volume={13 8},
  pages={
          2169-78
        }
}
Alemtuzumab (Campath-1H) is a humanized monoclonal antibody (Ab) directed against CD52 that depletes lymphocytes and other leukocytes, mainly by complement-dependent mechanisms. We investigated the influence of alemtuzumab (i) on ex vivo-expanded cynomolgus monkey regulatory T cells (Treg) generated for prospective use in adoptive cell therapy and (ii) on naturally occurring Treg following alemtuzumab infusion. Treg were isolated from PBMC and lymph nodes and expanded for two rounds. CD52… CONTINUE READING
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