Ex vivo expanded autologous polyclonal regulatory T cells suppress inhibitor formation in hemophilia

  title={Ex vivo expanded autologous polyclonal regulatory T cells suppress inhibitor formation in hemophilia},
  author={Debalina Sarkar and Moanaro Biswas and Gongxian Liao and Howard R Seay and George Q. Perrin and David M Markusic and Brad Hoffman and Todd M Brusko and Cox Terhorst and Roland W. Herzog},
  booktitle={Molecular therapy. Methods & clinical development},
Adoptive cell therapy utilizing ex vivo expanded polyclonal CD4+CD25+FOXP3+ regulatory T cells (Treg) is in use in clinical trials for the treatment of type 1 diabetes and prevention of graft vs host disease in bone marrow transplantation. Here we seek to evaluate this approach in the treatment of inherited protein deficiencies, i.e. hemophilia, which is often complicated by antibody formation against the therapeutic protein. Treg from mice that express GFP-marked FoxP3 were highly purified by… CONTINUE READING
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