Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cells.

@article{Trenado2006ExVC,
  title={Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cells.},
  author={Aur{\'e}lie Trenado and Muriel Sudres and Qizhi Tang and S{\'e}bastien Maury and Fr{\'e}d{\'e}ric Charlotte and Sylvie Gr{\'e}goire and Mark L. Bonyhadi and David Klatzmann and Beno{\^i}t L. Salomon and Jos{\'e} L Cohen},
  journal={Journal of immunology},
  year={2006},
  volume={176 2},
  pages={
          1266-73
        }
}
CD4+CD25+ immunoregulatory T cells (Tregs) can be administered to inhibit graft-vs-host disease (GVHD) while preserving graft-vs-leukemia activity after allogeneic bone marrow transplantation in mice. Preclinical studies suggest that it is necessary to infuse as many Tregs as conventional donor T cells to achieve a clinical effect on GVHD. Thus, it would be necessary to expand Tregs ex vivo before transplantation. Two strategies have been proposed: expansion of Tregs stimulated by anti-CD3/CD28… CONTINUE READING

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