Ex vivo chemosensitivity testing and gene expression profiling predict response towards adjuvant gemcitabine treatment in pancreatic cancer

@article{Michalski2008ExVC,
  title={Ex vivo chemosensitivity testing and gene expression profiling predict response towards adjuvant gemcitabine treatment in pancreatic cancer},
  author={Christoph W. Michalski and Mert Erkan and Danguole Sauliunaite and Thomas Giese and Rembert Stratmann and Christian Sartori and Nathalia A. Giese and Helmut Friess and Joerg Kleeff},
  journal={British Journal of Cancer},
  year={2008},
  volume={99},
  pages={760 - 767}
}
Efficacy of chemotherapy for pancreatic cancer may be improved by tailoring it to individual chemosensitivity profiles. Identification of nonresponders before initiation of treatment may help to avoid side effects. In this study, primary pancreatic cancer cells were isolated from 18 patients undergoing pancreaticoduodenectomy for pancreatic cancer. Eight commonly used pancreatic cancer cell lines were used as controls. Ex vivo chemosensitivity for gemcitabine, 5-fluorouracil, mitomycin-C… CONTINUE READING
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