Ex vivo characterization of tumor-derived melanoma antigen encoding gene-specific CD8+cells in patients with hepatocellular carcinoma.

@article{Zerbini2004ExVC,
  title={Ex vivo characterization of tumor-derived melanoma antigen encoding gene-specific CD8+cells in patients with hepatocellular carcinoma.},
  author={Alessandro Zerbini and Massimo Pilli and Paolo Soliani and Stefanie Ziegler and Guido Pelosi and Alessandra Orlandini and Cristina Cavallo and Jacopo Uggeri and Renato Scandroglio and Pellegrino Crafa and Giulio Cesare Spagnoli and Carlo Ferrari and Gabriele Missale},
  journal={Journal of hepatology},
  year={2004},
  volume={40 1},
  pages={102-9}
}
BACKGROUND/AIMS Members of the melanoma antigen encoding gene family are expressed in tumors of different histological types but not in normal tissue. For this reason, they are attractive targets for cancer immunotherapy. METHODS In the present study, we analyzed the expression of MAGE-1 and -3 genes in the hepatocellular carcinoma (HCC) tissue as well as frequency, phenotype and function of circulating and tumor infiltrating CD8+ cells specific for HLA-A1 and -A2 restricted epitopes of MAGE… CONTINUE READING

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