Ex vivo and in vivo IGF-I antisense RNA strategies for treatment of cancer in humans.

@article{Anthony1998ExVA,
  title={Ex vivo and in vivo IGF-I antisense RNA strategies for treatment of cancer in humans.},
  author={Donald D Anthony and Y X Pan and S G Wu and Fanxia Shen and Yu Jing Guo},
  journal={Advances in experimental medicine and biology},
  year={1998},
  volume={451},
  pages={
          27-34
        }
}
Two technical approaches to gene therapy for cancer utilize ex vivo and in vivo gene transfer methodology. This paper focuses on applicability and use of each of these approaches using an IGF-I antisense RNA strategy of treatment. Insulin-like growth factor I (IGF-I) and IGF-II have pivotal roles in cell proliferation and development (for review see 1–4). The preponderance of peptide synthesis and activity occur during fetal development. Protein synthesis is down-regulated in most mature… CONTINUE READING

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