Ex vivo MR determined apparent diffusion coefficients correlate with motor recovery mediated by intraspinal transplants of fibroblasts genetically modified to express BDNF.

@article{Schwartz2003ExVM,
  title={Ex vivo MR determined apparent diffusion coefficients correlate with motor recovery mediated by intraspinal transplants of fibroblasts genetically modified to express BDNF.},
  author={Eric D. Schwartz and Jed S. Shumsky and Suzanne W Wehrli and Alan R Tessler and Marion Murray and David B. Hackney},
  journal={Experimental neurology},
  year={2003},
  volume={182 1},
  pages={49-63}
}
The purpose of this study was to determine whether apparent diffusion coefficients (ADCs) in ex vivo spinal cord white matter, calculated from diffusion weighted MR (DWI) images, correlate with axonal growth and behavioral recovery following subtotal hemisection and transplantation of fibroblasts genetically modified to express brain derived neurotrophic factor (BDNF). These genetically modified fibroblasts have been shown to promote axonal growth, diminish retrograde degenerative changes in… CONTINUE READING
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