Ex Vivo bone formation in bovine trabecular bone cultured in a dynamic 3D bioreactor is enhanced by compressive mechanical strain.

@article{David2008ExVB,
  title={Ex Vivo bone formation in bovine trabecular bone cultured in a dynamic 3D bioreactor is enhanced by compressive mechanical strain.},
  author={Valentin David and Alain Guignandon and Aline Martin and Luc Malaval and Marie-Helene Lafage-Proust and Aline Rattner and Val Mann and Brendon Noble and David B. Jones and Laurence Vico},
  journal={Tissue engineering. Part A},
  year={2008},
  volume={14 1},
  pages={117-26}
}
Our aim was to test cell and trabecular responses to mechanical loading in vitro in a tissue bone explant culture model. We used a new three-dimensional culture model, the ZetOS system, which provides the ability to exert cyclic compression on cancellous bone cylinders (bovine sternum) cultured in forced flow circumfusion chambers, and allows to assess mechanical parameters of the cultivated samples. We evaluated bone cellular parameters through osteocyte viability test, gene and protein… CONTINUE READING
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