Ex Vivo Activity of Methotrexate versus Novel Antifolate Inhibitors of Dihydrofolate Reductase and Thymidylate Synthase against Childhood Leukemia Cells1

Abstract

Leukemic cells of 27 children [14 patients with initial acute lymphoblastic leukemia (iALL), 8 patients with relapsed ALL (rALL), and 5 patients with acute nonlymphoblastic leukemia (ANLL)] were evaluated for their sensitivity to methotrexate (MTX) and five novel antifolate drugs, which have the potential to circumvent MTX resistance. The novel antifolates… (More)

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Cite this paper

@inproceedings{Mauritz2005ExVA, title={Ex Vivo Activity of Methotrexate versus Novel Antifolate Inhibitors of Dihydrofolate Reductase and Thymidylate Synthase against Childhood Leukemia Cells1}, author={Robert Mauritz and Marcel W. Bekkenk and Marianne G. Rots and Rob Pieters and Enrico Mini and Christina H. van Zantwijk and Anjo J. P. Veerman and Godefridus J. Peters and Gerrit Jansen}, year={2005} }