Ex Situ and In Situ Characterization of Vaccine Suspensions in Pre-Filled Syringes.

@article{Lewis2017ExSA,
  title={Ex Situ and In Situ Characterization of Vaccine Suspensions in Pre-Filled Syringes.},
  author={Lavinia M. Lewis and Jianxin Guo and Ekaterina Torres and Jijun Wang and Hilbert Billones and Parag Kolhe and Anthony L Young and David W Bates and Andrew F W Parker and Shellie Rigby-Singleton},
  journal={Journal of pharmaceutical sciences},
  year={2017},
  volume={106 8},
  pages={2163-2167}
}
Ex situ and in situ techniques were used to characterize the suspended phase over time for a vaccine drug product supplied in syringes. Micro-computed tomography was used to characterize the suspended sediment in situ in the syringe, while traditional techniques such as particle size distribution, charge (zeta potential), settling rate, and front-faced fluorescence were used to characterize the suspension ex situ. In addition, analytical chemical measurements were conducted in parallel during… CONTINUE READING

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