Ewing sarcoma with novel translocation t(2;16) producing an in-frame fusion of FUS and FEV.

@article{Ng2007EwingSW,
  title={Ewing sarcoma with novel translocation t(2;16) producing an in-frame fusion of FUS and FEV.},
  author={Tony Ng and M J O'sullivan and Catherine J Pallen and Malcolm Hayes and Paul William Clarkson and Mark Winstanley and Poul H. B. Sorensen and Torsten O. Nielsen and Douglas E. Horsman},
  journal={The Journal of molecular diagnostics : JMD},
  year={2007},
  volume={9 4},
  pages={459-63}
}
Ewing family tumors are molecularly characterized by expression of chimeric transcripts generated by specific chromosomal translocations, most commonly involving fusion of the EWS gene to a member of the ETS family of transcription factors (including FLI1, ERG, ETV1, E1AF, and FEV). Approximately 85% of reported cases of Ewing sarcoma bear an EWS-FLI1 fusion. In rare cases, FUS can substitute for EWS, with translocation t(16;21)(p11;q24) producing a FUS-ERG fusion with no EWS rearrangement. We… CONTINUE READING
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