Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

@article{May1993EwingS1,
  title={Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.},
  author={William A. May and Mikhail Lev Gishizky and Stephen L Lessnick and Lynn B Lunsford and Brian C. Lewis and Olivier Delattre and Jessica Zucman and Gary Scott Thomas and Christopher T. Denny},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 12},
  pages={
          5752-6
        }
}
The 11;22 chromosomal translocation specifically linked to Ewing sarcoma and primitive neuroectodermal tumor results in a chimeric molecule fusing the amino-terminal-encoding portion of the EWS gene to the carboxyl-terminal DNA-binding domain encoded by the FLI1 gene. We have isolated a fourth EWS-FLI1 fusion cDNA that is structurally distinct from the three forms previously described. To determine the transforming activity of this gene, alternative forms of the EWS-FLI1 fusion were transduced… CONTINUE READING
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