Evolving therapeutic strategies to improve nonsteroidal anti-inflammatory drug safety.

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) possess potent anti-inflammatory and analgesic properties through inhibition of cyclooxygenase enzymes (COX-1 and COX-2), which are responsible for synthesis of proinflammatory mediators. NSAIDs are frequently used for treatment of acute and chronic pain conditions. However, their use is associated with serious… (More)
DOI: 10.1097/MJT.0000000000000123

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