Evolving strategies for the management of hand-foot skin reaction associated with the multitargeted kinase inhibitors sorafenib and sunitinib.

@article{Lacouture2008EvolvingSF,
  title={Evolving strategies for the management of hand-foot skin reaction associated with the multitargeted kinase inhibitors sorafenib and sunitinib.},
  author={Mario E. Lacouture and Shenhong L Wu and Caroline Robert and Michael B. Atkins and Heidi H Kong and J. Guitart and Claus Garbe and A. H. W. Hauschild and Igor J. Puzanov and D. Alexandrescu and Roger T. Anderson and Laura C. Wood and Janice P Dutcher},
  journal={The oncologist},
  year={2008},
  volume={13 9},
  pages={1001-11}
}
The multitargeted kinase inhibitors (MKIs) sorafenib and sunitinib have shown benefit in patients with renal cell carcinoma, hepatocellular carcinoma (sorafenib), and gastrointestinal stromal tumor (sunitinib). Their efficacy in other malignancies is currently being investigated because of their broad range of activity. The effectiveness of these drugs is somewhat diminished by the development of a variety of toxicities, most notably hand-foot skin reaction (HFSR). Although HFSR does not appear… CONTINUE READING

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