Evolving pharmacological approaches in gastroesophageal reflux disease.

  title={Evolving pharmacological approaches in gastroesophageal reflux disease.},
  author={Ege Altan and Kathleen Blondeau and Ans Pauwels and Ricard Farr{\'e} and Jan Tack},
  journal={Expert opinion on emerging drugs},
  volume={17 3},
INTRODUCTION Proton pump inhibitors (PPIs) have considerably improved quality of life in patients with gastroesophageal reflux disease (GERD). However, many patients remain symptomatic despite standard PPI therapy. AREAS COVERED This review focuses on evolving therapeutic strategies related to the pathophysiological processes of GERD and insufficient response to PPIs. Several clinical trials evaluated new PPI formulations and newer types of acid-suppressive drugs. These studies have evaluated… CONTINUE READING

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