Evolving metformin treatment strategies in type-2 diabetes: from immediate-release metformin monotherapy to extended-release combination therapy.

@article{Chacra2014EvolvingMT,
  title={Evolving metformin treatment strategies in type-2 diabetes: from immediate-release metformin monotherapy to extended-release combination therapy.},
  author={Ant{\^o}nio Roberto Chacra},
  journal={American journal of therapeutics},
  year={2014},
  volume={21 3},
  pages={198-210}
}
Over the last 40 years, metformin has revolutionized the treatment of type-2 diabetes worldwide and is still the most influential oral antidiabetic drug today. International guidelines now recommend that patients with type-2 diabetes are started on metformin therapy as soon as they are diagnosed, as it has been shown to improve long-term clinical outcomes… CONTINUE READING