Evolving immunosuppressive microenvironment during human cervical carcinogenesis

  title={Evolving immunosuppressive microenvironment during human cervical carcinogenesis},
  author={Akiko Kobayashi and Vivian A. Weinberg and Tere Darragh and Karen K. Smith-McCune},
  journal={Mucosal Immunology},
Chronic infection with human papillomavirus (HPV) can result in cervical cancer. To understand how HPV escapes immune eradication, we examined biophenotypes of immune cells in human normal cervix, cervical intraepithelial neoplasia (CIN), and cancer. Expression and cellular localization of Forkhead box protein-3 (FOXP3), indolamine 2,3-dioxygenase (IDO), interleukin (IL)-10, and interferon (IFN)-γ were examined by immunofluorescence and immunohistochemistry. Mean cell densities of stromal FOXP3… CONTINUE READING


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