Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data

@article{Dai2005EvolvingGD,
  title={Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data},
  author={Manhong Dai and Pinglang Wang and Andrew Dallas Boyd and Georgi Kostov and Brian Athey and Edward G. Jones and William E. Bunney and Richard M. Myers and Terence P. Speed and Huda Akil and Stanley J. Watson and Fan Meng},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={e175 - e175}
}
Genome-wide expression profiling is a powerful tool for implicating novel gene ensembles in cellular mechanisms of health and disease. The most popular platform for genome-wide expression profiling is the Affymetrix GeneChip. However, its selection of probes relied on earlier genome and transcriptome annotation which is significantly different from current knowledge. The resultant informatics problems have a profound impact on analysis and interpretation the data. Here, we address these… CONTINUE READING
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