Evolving concepts on the pathophysiology of absence seizures: the cortical focus theory.

  title={Evolving concepts on the pathophysiology of absence seizures: the cortical focus theory.},
  author={Hanneke K. M. Meeren and Gilles L J M van Luijtelaar and Fernando H. Lopes da Silva and Anton M. L. Coenen},
  journal={Archives of neurology},
  volume={62 3},
Four main theories on the pathophysiology of generalized absence seizures have been proposed. The "centrencephalic" theory, proposed in 1954, suggested that discharges originate from a deep-seated diffusely projecting subcortical pacemaker in the midline thalamus. This concept was refined in 1991 with the "thalamic clock" theory, implying that the reticular thalamic nucleus contains the pacemaker cells for the thalamic clock, imposing its rhythm to the cortex. According to other investigators… CONTINUE READING
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Impairment of intracortical GABAergic inhibition in a rat model of absence epilepsy

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2 Excerpts

Role of the thalamic reticular nucleus in the generation of rhythmic thalamocortical activities subserving spike and waves

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1 Excerpt

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