Evolving concepts of the renin-angiotensin system. Focus on renal and vascular mechanisms.

@article{Dzau1988EvolvingCO,
  title={Evolving concepts of the renin-angiotensin system. Focus on renal and vascular mechanisms.},
  author={Victor J. Dzau},
  journal={American journal of hypertension},
  year={1988},
  volume={1 4 Pt 2},
  pages={334S-337S}
}
The traditional concept of the renin-angiotensin system (RAS) is a circulation-borne endocrine system, the components of which are secreted by various organs. The product of this biochemical cascade, angiotensin II, acts on specific receptors on multiple target organs. Activation of this circulating system has been shown to result in vasoconstriction and hypertension. In addition to this endocrine system, evidence is emerging that the renin-angiotensin system also exists at multiple local… CONTINUE READING
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