Evolving concepts of partial agonism. The beta-adrenergic receptor as a paradigm.

@article{Jasper1992EvolvingCO,
  title={Evolving concepts of partial agonism. The beta-adrenergic receptor as a paradigm.},
  author={Jeffrey R. Jasper and Paul A. Insel},
  journal={Biochemical pharmacology},
  year={1992},
  volume={43 2},
  pages={119-30}
}
The exact mechanism of receptor activation at the molecular level are still not known, nor do we completely understand the precise factors that distinguish agonist- and partial agonist-induced activation. Nevertheless, recent years have brought forth an explosion of new information regarding beta-adrenergic receptor structure and ligand-induced activation. Partial agonists are likely intermediate in their ability to interact with crucial serine residues (Ser204 and Ser207) on the beta… CONTINUE READING

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