Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.

@article{Ferguson2001EvolvingCI,
  title={Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.},
  author={Stephen S. G. Ferguson},
  journal={Pharmacological reviews},
  year={2001},
  volume={53 1},
  pages={
          1-24
        }
}
G protein-coupled receptors (GPCRs) are seven transmembrane proteins that form the largest single family of integral membrane receptors. GPCRs transduce information provided by extracellular stimuli into intracellular second messengers via their coupling to heterotrimeric G proteins and the subsequent regulation of a diverse variety of effector systems. Agonist activation of GPCRs also initiates processes that are involved in the feedback desensitization of GPCR responsiveness, the… CONTINUE READING

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References

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SHOWING 1-10 OF 272 REFERENCES

Differential regulation of b 2 - adrenergic and angiotensin II type 1 A receptor trafficking and resensitization : Role of carboxyl - terminal domains

PH Anborgh, L Dale, J Seachrist, Ferguson SSG
  • Mol Endocrinol
  • 2000
VIEW 15 EXCERPTS
HIGHLY INFLUENTIAL

Regulation and intracellular trafficking pathways of the endothelin receptors.

  • The Journal of biological chemistry
  • 2000
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

b 2 - Adrenergic receptor internalization , endosomal sorting and plasma membrane recycling are regulated by Rab GTPases

J Seachrist, PH Anborgh, Ferguson SSG
  • J Biol Chem
  • 2000
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Adaptors for clathrin-mediated traffic.

  • Annual review of cell and developmental biology
  • 1999
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

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