Evolving approaches of hematopoietic stem cell-based therapies to induce tolerance to organ transplants: the long road to tolerance.

@article{Leventhal2013EvolvingAO,
  title={Evolving approaches of hematopoietic stem cell-based therapies to induce tolerance to organ transplants: the long road to tolerance.},
  author={Joseph R. Leventhal and Jaime Miller and Micheal Abecassis and David J. Tollerud and Suzanne T. Ildstad},
  journal={Clinical pharmacology and therapeutics},
  year={2013},
  volume={93 1},
  pages={36-45}
}
The immunoregulatory properties of hematopoietic stem cells (HSCs) have been recognized for more than 60 years, beginning in 1945, when Owen reported that genetically disparate freemartin cattle sharing a common placenta were red blood cell chimeras. In 1953, Billingham, Brent, and Medawar demonstrated that murine neonatal chimeras prepared by infusion of donor-derived hematopoietic cells exhibited donor-specific tolerance to skin allografts. Various approaches using HSCs in organ… CONTINUE READING

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The immunoregulatory properties of hematopoietic stem cells ( HSCs ) have been recognized for more than 60 years , beginning in 1945 , when Owen reported that genetically disparate freemartin cattle sharing a common placenta were red blood cell chimeras .
The immunoregulatory properties of hematopoietic stem cells ( HSCs ) have been recognized for more than 60 years , beginning in 1945 , when Owen reported that genetically disparate freemartin cattle sharing a common placenta were red blood cell chimeras .
The immunoregulatory properties of hematopoietic stem cells ( HSCs ) have been recognized for more than 60 years , beginning in 1945 , when Owen reported that genetically disparate freemartin cattle sharing a common placenta were red blood cell chimeras .
The immunoregulatory properties of hematopoietic stem cells ( HSCs ) have been recognized for more than 60 years , beginning in 1945 , when Owen reported that genetically disparate freemartin cattle sharing a common placenta were red blood cell chimeras .
The immunoregulatory properties of hematopoietic stem cells ( HSCs ) have been recognized for more than 60 years , beginning in 1945 , when Owen reported that genetically disparate freemartin cattle sharing a common placenta were red blood cell chimeras .
The immunoregulatory properties of hematopoietic stem cells ( HSCs ) have been recognized for more than 60 years , beginning in 1945 , when Owen reported that genetically disparate freemartin cattle sharing a common placenta were red blood cell chimeras .
The immunoregulatory properties of hematopoietic stem cells ( HSCs ) have been recognized for more than 60 years , beginning in 1945 , when Owen reported that genetically disparate freemartin cattle sharing a common placenta were red blood cell chimeras .
The immunoregulatory properties of hematopoietic stem cells ( HSCs ) have been recognized for more than 60 years , beginning in 1945 , when Owen reported that genetically disparate freemartin cattle sharing a common placenta were red blood cell chimeras .
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