Evolvability and hierarchy in rewired bacterial gene networks

  title={Evolvability and hierarchy in rewired bacterial gene networks},
  author={Mark Isalan and Caroline Lemerle and Konstantinos Michalodimitrakis and Carsten Horn and Pedro Beltr{\~a}o and Emanuele Raineri and Mireia Garriga-Canut and Luis J Serrano},
Sequencing DNA from several organisms has revealed that duplication and drift of existing genes have primarily moulded the contents of a given genome. Though the effect of knocking out or overexpressing a particular gene has been studied in many organisms, no study has systematically explored the effect of adding new links in a biological network. To explore network evolvability, we constructed 598 recombinations of promoters (including regulatory regions) with different transcription or… CONTINUE READING


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