Evolutionary turnover of mammalian transcription start sites.

  title={Evolutionary turnover of mammalian transcription start sites.},
  author={Martin C. Frith and Jasmina Ponjavic and D. Fredman and Chikatoshi Kai and Jun Kawai and Piero Carninci and Yoshihide Hayashizaki and Albin Sandelin},
  journal={Genome research},
  volume={16 6},
Alignments of homologous genomic sequences are widely used to identify functional genetic elements and study their evolution. Most studies tacitly equate homology of functional elements with sequence homology. This assumption is violated by the phenomenon of turnover, in which functionally equivalent elements reside at locations that are nonorthologous at… CONTINUE READING