Evolutionary trace annotation of protein function in the structural proteome.

@article{Erdin2010EvolutionaryTA,
  title={Evolutionary trace annotation of protein function in the structural proteome.},
  author={Serkan Erdin and R. Matthew Ward and Eric Venner and Olivier Lichtarge},
  journal={Journal of molecular biology},
  year={2010},
  volume={396 5},
  pages={1451-73}
}
By design, structural genomics (SG) solves many structures that cannot be assigned function based on homology to known proteins. Alternative function annotation methods are therefore needed and this study focuses on function prediction with three-dimensional (3D) templates: small structural motifs built of just a few functionally critical residues. Although experimentally proven functional residues are scarce, we show here that Evolutionary Trace (ET) rankings of residue importance are… CONTINUE READING