Evolutionary trace analysis of TGF-beta and related growth factors: implications for site-directed mutagenesis.

@article{Innis2000EvolutionaryTA,
  title={Evolutionary trace analysis of TGF-beta and related growth factors: implications for site-directed mutagenesis.},
  author={Claudine Innis and Jiye Shi and Tom L. Blundell},
  journal={Protein engineering},
  year={2000},
  volume={13 12},
  pages={
          839-47
        }
}
The TGF-beta family of growth factors contains a large number of homologous proteins, grouped in several subfamilies on the basis of sequence identity. These subgroups can be combined into three broader groups of related cytokines, with marked specificities for their cellular receptors: the TGF-betas, the activins and the BMPs/GDFs. Although structural information is available for some members of the TGF-beta family, very little is known about the way in which these growth factors interact with… CONTINUE READING

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