Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary

@article{Hallbk1991EvolutionarySO,
  title={Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary},
  author={Finn Hallb{\"o}{\"o}k and Carlos F. Ib{\'a}{\~n}ez and H{\aa}kan Persson},
  journal={Neuron},
  year={1991},
  volume={6},
  pages={845-858}
}

Figures and Tables from this paper

Cloning and Expression of a Novel Neurotrophin, NT-7, from Carp

TLDR
The cloning of a novel neurotrophin from the fish Cyprinus carpio (carp), which shared about 66% amino acid identity to Xiphophorus NGF and NT-6, and possesses structural characteristics common to all known neurotrophins, such as six conserved cysteine residues and the flanking conserved sequences.

Brain-Derived Neurotrophic Factor ls More Highly Conserved in Structure and Function than Nerve Growth Factor During Vertebrate Evolution

TLDR
The retrograde extrapolation of these data indicates that NGF and BDNF evolved at strikingly different rates ftom a common ancestral gene about 600 million years ago and reached an optimized structure later than BDNF.

Brain‐Derived Neurotrophic Factor Is More Highly Conserved in Structure and Function than Nerve Growth Factor During Vertebrate Evolution

TLDR
The DNA‐deduced amino acid sequences of processed mature fish NGF and BDNF showed, compared to mouse, 63% and 90% identity, respectively, indicating that NGF had reached an optimized structure later than BDNF.

Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

  • N. IpC. Ibáñez S. Squinto
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1992
TLDR
A neurotrophin is isolated from both human and rat genomic DNA that appears to represent the mammalian counterpart of Xenopus/viper NT-4, which has many unusual features compared to the previously identified neurotrophins and is less conserved evolutionarily than the other neurotrophs.

Function and evolution in the NGF family and its receptors

  • T. Ebendal
  • Biology
    Journal of neuroscience research
  • 1992
TLDR
Cladistic analysis of likely phylogenies within the neurotrophins shows BDNF and NT‐4 to be most closely related whereas NGF may be the sister group to NT‐3, BDNF, andNT‐4.

Neurotrophins and their Receptors

TLDR
Using this approach, NGF has been shown to expert a trophic stimulation for cholinergic neurons in the brain and BDNF and its receptor could, in a paracrine/autocrine fashion, play a role in kindling-associated neural plasticity and in neuronal protection following ischemic and hypoglycemic insults.

Neurotrophin-6 is a new member of the nerve growth factor family

TLDR
The cloning of neurotrophin-6 (NT-6), a new mem-ber of this family from the teleost fish Xiphophorus is reported, which has a spectrum of actions similar to NGF on chick sympathetic and sensory neurons, albeit with a lower potency.
...

References

SHOWING 1-10 OF 159 REFERENCES

Structure and expression of the chicken beta nerve growth factor gene.

TLDR
In the adult avian brain, NGF mRNA is found at higher concentration in the optic tectum and cerebellum than in the cortex and hippocampus, which suggests a correlation between NGF expression and the density of sympathetic innervation in peripheral organs, in analogy with findings for mammalian tissues.

Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain.

TLDR
A pool of degenerate oligonucleotides representing all possible codons in regions of homology between brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) to prime rat hippocampal cDNAs to represent a family of neurotrophic factors that may cooperate to support the development and maintenance of the vertebrate nervous system.

Molecular cloning of bovine and chick nerve growth factor (NGF): delineation of conserved and unconserved domains and their relationship to the biological activity and antigenicity of NGF.

TLDR
The carboxy termini of bovine and chick NGF differ from that of mouse NGF, the changes in the amino acid sequences suggest that chick and bovines NGF are probably not processed by the gamma‐subunit and that no 7S complex can be formed as in the mouse submandibular gland.

Structure and developmental expression of the chicken NGF receptor.

Rat β‐nerve growth factor sequence and site of synthesis in the adult hippocampus

TLDR
In situ hydridization with a rat‐specific oligodeoxynucleotide indicated high levels of NGF mRNA synthesis in both hippocampal granule and pyramidal cell layers, consistent with one role for NGF in the CNS as a neuronally released, retrogradely transported neurotrophic factor for basal forebrain cholinergic neurons.

Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family

TLDR
Taking advantage of sequence identities between NGF and BDNF, a third member of this family of secretory proteins is identified, which is named neurotrophin-3, and a remarkable number of amino acid identities are revealed, including all cys-teine residues.

Cobra nerve growth factor: Structure and evolutionary comparison

TLDR
Primer extension analysis indicates a single NGF transcript in the cobra venom gland, and the structure of the predicted cobra precursor resembles that of the mouse prohormone, with a highly conserved mature NGF protein at the C‐terminus.

Structure‐function studies of nerve growth factor: functional importance of highly conserved amino acid residues.

TLDR
The Trp mutated proteins retained 15‐60% of receptor binding and 40‐80% of biological activity, indicating that the Trp residues are not essential for NGF activity, however, replacement of Trp20 significantly reduced the amount of NGF in the medium, suggesting that this residue may be important for protein stability.
...