Evolutionary sequence comparisons using high-density oligonucleotide arrays

@article{Hacia1998EvolutionarySC,
  title={Evolutionary sequence comparisons using high-density oligonucleotide arrays},
  author={Joseph G. Hacia and Wojciech Makalowski and Keith Edgemon and Michael R Erdos and Christiane M. Robbins and Stephen P. A. Fodor and Lawrence C. Brody and Francis S. Collins},
  journal={Nature Genetics},
  year={1998},
  volume={18},
  pages={155-158}
}
We explored the utility of high-density oligonucleotide arrays (DMA chips) for obtaining sequence information from homologous genes in closely related species. Orthologues of the human BRCA1 exon 11, all approximately 3.4 kb in length and ranging from 98.2% to 83.5% nucleotide identity, were subjected to hybridization-based and conventional… CONTINUE READING