Evolutionary relationships of endemic/epidemic and sylvatic dengue viruses.

  title={Evolutionary relationships of endemic/epidemic and sylvatic dengue viruses.},
  author={Eryu Wang and Haolin Ni and Ruliang Xu and Alan D. T. Barrett and Stanley J. Watowich and Duane J. Gubler and Scott C. Weaver},
  journal={Journal of virology},
  volume={74 7},
Endemic/epidemic dengue viruses (DEN) that are transmitted among humans by the mosquito vectors Aedes aegypti and Aedes albopictus are hypothesized to have evolved from sylvatic DEN strains that are transmitted among nonhuman primates in West Africa and Malaysia by other Aedes mosquitoes. We tested this hypothesis with phylogenetic studies using envelope protein gene sequences of both endemic/epidemic and sylvatic strains. The basal position of sylvatic lineages of DEN-1, -2, and -4 suggested… CONTINUE READING
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