Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family.

@article{Gold1987EvolutionaryRB,
  title={Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family.},
  author={Daniel P. Gold and Hans Clevers and Balbino Alarc{\'o}n and Sabrina Dunlap and Jiř{\'i} Novotn{\'y} and Alan F. Williams and Cox Terhorst},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 21},
  pages={
          7649-53
        }
}
Antigen receptors on the surface of the thymus-derived (T) lymphocytes are associated with small integral membrane proteins called the T3 (CD3) gamma, delta, epsilon, and zeta chains. After interaction of the T-cell receptor with antigen, the T3 proteins are believed to transfer an activation signal to the intracellular compartment. In previous studies, the human gamma, epsilon, and delta chains have been cloned along with the mouse delta chain, but a relationship between these sequences and… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 32 CITATIONS