Evolutionary programming as a platform for in silico metabolic engineering

@article{Patil2005EvolutionaryPA,
  title={Evolutionary programming as a platform for in silico metabolic engineering},
  author={Kiran Raosaheb Patil and Isabel Rocha and Jochen F{\"o}rster and Jens Nielsen},
  journal={BMC Bioinformatics},
  year={2005},
  volume={6},
  pages={308 - 308}
}
Through genetic engineering it is possible to introduce targeted genetic changes and hereby engineer the metabolism of microbial cells with the objective to obtain desirable phenotypes. However, owing to the complexity of metabolic networks, both in terms of structure and regulation, it is often difficult to predict the effects of genetic modifications on the resulting phenotype. Recently genome-scale metabolic models have been compiled for several different microorganisms where structural and… CONTINUE READING
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