Evolutionary origin of the structure and function of gonadotropin-inhibitory hormone: insights from lampreys.

@article{Osugi2012EvolutionaryOO,
  title={Evolutionary origin of the structure and function of gonadotropin-inhibitory hormone: insights from lampreys.},
  author={Tomohiro Osugi and Dana Daukss and Kristen Gazda and Takayoshi Ubuka and Takayoshi Kosugi and Masumi Nozaki and Stacia A. Sower and Kazuyoshi Tsutsui},
  journal={Endocrinology},
  year={2012},
  volume={153 5},
  pages={
          2362-74
        }
}
Gonadotropin (GTH)-inhibitory hormone (GnIH) is a novel hypothalamic neuropeptide that inhibits GTH secretion in mammals and birds by acting on gonadotropes and GnRH neurons within the hypothalamic-pituitary-gonadal axis. GnIH and its orthologs that have an LPXRFamide (X = L or Q) motif at the C terminus (LPXRFamide peptides) have been identified in representative species of gnathostomes. However, the identity of an LPXRFamide peptide had yet to be identified in agnathans, the most ancient… 

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