Evolutionary origin of endochondral ossification: the transdifferentiation hypothesis

@article{CervantesDaz2016EvolutionaryOO,
  title={Evolutionary origin of endochondral ossification: the transdifferentiation hypothesis},
  author={Fret Cervantes-D{\'i}az and Pedro Gonzalo Palacios Contreras and Sylvain Marcellini},
  journal={Development Genes and Evolution},
  year={2016},
  volume={227},
  pages={121-127}
}
The vertebrate endoskeleton results from the piecemeal assembly of bone and cartilage as well as additional types of calcified extracellular matrices produced by seemingly hybrid cell types of intermediate phenotypes between osteoblasts and chondrocytes. Hence, shedding light on the emergence and subsequent diversification of skeletal tissues represents a major challenge in vertebrate evolutionary developmental biology. A 150-year-old debate in the field was recently solved by lineage tracing… 
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