Evolutionary origin of cAMP-based chemoattraction in the social amoebae.

  title={Evolutionary origin of cAMP-based chemoattraction in the social amoebae.},
  author={Elisa Alvarez-Curto and Daniel E Rozen and Allyson V. Ritchie and Celine Fouquet and Sandra L. Baldauf and Pauline Schaap},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 18},
Phenotypic novelties can arise if integrated developmental pathways are expressed at new developmental stages and then recruited to serve new functions. We analyze the origin of a novel developmental trait of Dictyostelid amoebae: the evolution of cAMP as a developmental chemoattractant. We show that cAMP's role of attracting starving amoebae arose through recruitment of a pathway that originally evolved to coordinate fruiting body morphogenesis. Orthologues of the high-affinity cAMP receptor… CONTINUE READING


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