Evolutionary mechanisms underlying secondary metabolite diversity.

  title={Evolutionary mechanisms underlying secondary metabolite diversity.},
  author={Holger Jenke-Kodama and Rolf M{\"u}ller and Elke Dittmann},
  journal={Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques},
  pages={119, 121-40}
The enormous chemical diversity and the broad range of biological activities of secondary metabolites raise many questions about their role in nature and the specific traits leading to their evolution. The answers to these questions will not only be of fundamental interest but may also provide lessons that could help to improve the screening protocols of pharmaceutical companies and strategies for rational secondary metabolite engineering. In this review, we try to dissect evolutionary… CONTINUE READING