Evolutionary mechanism unifies the hallmarks of cancer.

@article{Horne2015EvolutionaryMU,
  title={Evolutionary mechanism unifies the hallmarks of cancer.},
  author={Steven D. Horne and Sarah A Pollick and Henry H Heng},
  journal={International journal of cancer},
  year={2015},
  volume={136 9},
  pages={2012-21}
}
The basis for the gene mutation theory of cancer that dominates current molecular cancer research consists of: the belief that gene-level aberrations such as mutations are the main cause of cancers, the concept that stepwise gene mutation accumulation drives cancer progression, and the hallmarks of cancer. The research community swiftly embraced the hallmarks of cancer, as such synthesis has supported the notions that common cancer genes are responsible for the majority of cancers and the… CONTINUE READING
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