Evolutionary meandering of intermolecular interactions along the drift barrier.

@article{Lynch2015EvolutionaryMO,
  title={Evolutionary meandering of intermolecular interactions along the drift barrier.},
  author={Michael Lynch and Kyle Hagner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 1},
  pages={E30-8}
}
Many cellular functions depend on highly specific intermolecular interactions, for example transcription factors and their DNA binding sites, microRNAs and their RNA binding sites, the interfaces between heterodimeric protein molecules, the stems in RNA molecules, and kinases and their response regulators in signal-transduction systems. Despite the need for complementarity between interacting partners, such pairwise systems seem to be capable of high levels of evolutionary divergence, even when… CONTINUE READING