Evolutionary matches of enzyme and transporter capacities to dietary substrate loads in the intestinal brush border.

@article{Weiss1998EvolutionaryMO,
  title={Evolutionary matches of enzyme and transporter capacities to dietary substrate loads in the intestinal brush border.},
  author={Shimon Weiss and Edward. A. Lee and Jared Diamond},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 5},
  pages={2117-21}
}
Safety factors of enzymes and transporters are defined as the ratio of Vmax (maximal reaction rates at high substrate concentrations) to the reaction rate under actual physiological conditions. Although corresponding safety factors have been measured for macroscopic biological structures and for human-engineered structures, safety factors have been little… CONTINUE READING