Evolutionary history of the TBP-domain superfamily

@inproceedings{Brindefalk2013EvolutionaryHO,
  title={Evolutionary history of the TBP-domain superfamily},
  author={Bj{\"o}rn Brindefalk and Benoit H. Dessailly and Corin Yeats and Christine A. Orengo and Finn Werner and Anthony M. Poole},
  booktitle={Nucleic acids research},
  year={2013}
}
  • Björn Brindefalk, Benoit H. Dessailly, +3 authors Anthony M. Poole
  • Published in Nucleic acids research 2013
  • Biology, Medicine
  • The TATA binding protein (TBP) is an essential transcription initiation factor in Archaea and Eucarya. Bacteria lack TBP, and instead use sigma factors for transcription initiation. TBP has a symmetric structure comprising two repeated TBP domains. Using sequence, structural and phylogenetic analyses, we examine the distribution and evolutionary history of the TBP domain, a member of the helix-grip fold family. Our analyses reveal a broader distribution than for TBP, with TBP-domains being… CONTINUE READING

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