Evolutionary history of Ebola virus

@article{Li2013EvolutionaryHO,
  title={Evolutionary history of Ebola virus},
  author={Y. Li and S. Chen},
  journal={Epidemiology and Infection},
  year={2013},
  volume={142},
  pages={1138 - 1145}
}
  • Y. Li, S. Chen
  • Published 2013
  • Biology, Medicine
  • Epidemiology and Infection
SUMMARY Since Ebola virus was discovered in 1970s, the virus has persisted in Africa and sporadic fatal outbreaks in humans and non-human primates have been reported. However, the evolutionary history of Ebola virus remains unclear. In this study, 27 Ebola virus strains with complete glycoprotein genes, including five species (Zaire, Sudan, Reston, Tai Forest, Bundibugyo), were analysed. Here, we propose a hypothesis of the evolutionary history of Ebola virus which will be helpful to… Expand
New Perspectives on Ebola Virus Evolution
TLDR
This study inferred the maximum likelihood phylogeny of 96 nonredundant GP gene sequences representing each of the outbreaks since 1976 up to the end of 2014 and concluded that although the mucin-like domain of GP1 is essential for EBOV in vivo, it evolves rapidly without losing its twin functions: providing O-linked glycosylation sites and a flexible surface. Expand
Ebola and Marburg Virus: A Brief Review
TLDR
The frequency, the rapid spread of epidemics, the mobilization of human, health and socioeconomic resources, the implementation of security measures, an effective management, and especially an effective vaccine against these viruses and their variants militate in favor of the preparation and the response. Expand
Ebolavirus Evolution: Past and Present
TLDR
Given the unprecedented size and spread of the outbreak, as well as the extended period of replication in human hosts, specific attention is given to the 2014–2015 West African outbreak variant (Makona). Expand
Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone
TLDR
The 2014 Ebola virus has become more phylogenetically and genetically diverse from July to November 2014, characterized by the emergence of multiple novel lineages and the sharp increase in genetic diversity of the 2014 EBOV. Expand
Ebola, the Negative Stranded RNA Virus
Ebola virus (EBV) is a deadly virus that has resulted in a number of deaths during its outbreaks in Africa in 2014–2016 and 2018–2019. This virus causes a hemorrhagic fever like other pathogenicExpand
Ebola virus disease 2014
TLDR
The characteristics of the viruses, pathogenesis, diagnosis, treatment, and the cases reported in health care workers (HCW) are described, as well as a summary of outbreaks of the virus since its discovery, including these last two outbreaks in Africa. Expand
Transmission of ebola virus disease: an overview.
TLDR
As of late October 2014, the World Health Organization reported 13,567 suspected cases and 4922 deaths, although the agency believes that this substantially understates the magnitude of the outbreak. Expand
Ebola virus outbreak, updates on current therapeutic strategies
TLDR
What is known about the nature of the virus, phylogenetic classification, genomic organization and replication, disease transmission, and viral entry are discussed and the current approaches and efforts, in the development of therapeutics, to control the outbreak are highlighted. Expand
Impact of spatial dispersion, evolution, and selection on Ebola Zaire Virus epidemic waves
TLDR
It is shown that, although patterns of spatial dispersion throughout Africa varied, the evolution of the virus has largely been characterized by neutral genetic drift, and the radical emergence of more transmissible variants is unlikely, a positive finding, which is increasingly important on the verge of vaccine deployment. Expand
Ebola virus (EBOV) infection: Therapeutic strategies
TLDR
Much has to be learned from the mechanism of action of the compounds active against VSV (vesicular stomatitis virus), a virus belonging to the rhabdoviridae, that in its mode of replication could be exemplary for the replication of filoviraceae. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 45 REFERENCES
Isolation and phylogenetic characterization of Ebola viruses causing different outbreaks in Gabon.
TLDR
No genetic variability was detected between virus samples taken during an individual outbreak of Ebola hemorrhagic fever in Gabon, indicating that each of the three outbreaks should be considered an independent emergence of a different Ebola virus of the Zaire subtype. Expand
Fruit bats as reservoirs of Ebola virus
TLDR
Evidence of asymptomatic infection by Ebola virus is found in three species of fruit bat, indicating that these animals may be acting as a reservoir for this deadly virus. Expand
Isolation and partial characterisation of a new strain of Ebola virus
TLDR
A new strain of Ebola virus is isolated from a non-fatal human case infected during the autopsy of a wild chimpanzee in the Côte-d'Ivoire, the first time that a human infection has been connected to naturally-infected monkeys in Africa. Expand
The origin and evolution of Ebola and Marburg viruses.
TLDR
The rate of nonsynonymous substitutions for the glycoprotein gene of Ebola virus was estimated to be 3.6 x 10(-5) per site per year, which suggests that purifying selection has operated on Marburg virus during evolution. Expand
Emergence of subtype Zaire Ebola virus in Gabon.
Gabon has recently been struck three times by Ebola hemorrhagic fever. The first isolate originating from the 1994 outbreak has been subjected to molecular characterization of its GP and VP24 genes.Expand
Preliminary report: isolation of Ebola virus from monkeys imported to USA
TLDR
This incident, the first in which a filovirus has been isolated from non-human primates without deliberate infection, raises the possibility that cynomolgus monkeys could be a reservoir of Ebola virus infection. Expand
The changing nature of avian influenza A virus (H5N1).
TLDR
The complex dynamics and changing nature of the H5N1 virus that may contribute to the emergence of pandemic strains are reviewed. Expand
Isolates of Zaire ebolavirus from wild apes reveal genetic lineage and recombinants
TLDR
The first ZEBOV sequences isolated from great ape carcasses in the Gabon/Congo region that belong to a previously unrecognized genetic lineage are described, suggesting that virus spillover from the reservoir has occurred more than once, as predicted by the multiple emergence hypothesis. Expand
Newly Discovered Ebola Virus Associated with Hemorrhagic Fever Outbreak in Uganda
TLDR
Due to the sequence divergence of this new virus relative to all previously recognized ebolaviruses, these findings have important implications for design of future diagnostic assays to monitor Ebola HF disease in humans and animals, and ongoing efforts to develop effective antivirals and vaccines. Expand
Complete genome sequence of an Ebola virus (Sudan species) responsible for a 2000 outbreak of human disease in Uganda.
TLDR
Comparisons of the amino acid sequences of encoded gene products shows that there is a comparable level of identity or similarity between Ebola virus species, with Sudan and Zaire actually showing a slightly closer relationship to the Reston species than to one another. Expand
...
1
2
3
4
5
...