Evolutionary history and metabolic insights of ancient mammalian uricases.

  title={Evolutionary history and metabolic insights of ancient mammalian uricases.},
  author={James T. Kratzer and Miguel A Lanaspa and Michael N. Murphy and Christina Cicerchi and Christina L. Graves and Peter A. Tipton and Eric A. Ortlund and Richard J Johnson and Eric A. Gaucher},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 10},
Uricase is an enzyme involved in purine catabolism and is found in all three domains of life. Curiously, uricase is not functional in some organisms despite its role in converting highly insoluble uric acid into 5-hydroxyisourate. Of particular interest is the observation that apes, including humans, cannot oxidize uric acid, and it appears that multiple, independent evolutionary events led to the silencing or pseudogenization of the uricase gene in ancestral apes. Various arguments have been… CONTINUE READING
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