Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes

@article{Anantharaman2002EvolutionaryHS,
  title={Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes},
  author={Vivek Anantharaman and L. Aravind},
  journal={Genome Biology},
  year={2002},
  volume={4},
  pages={R11 - R11}
}
Peptidoglycan is hydrolyzed by a diverse set of enzymes during bacterial growth, development and cell division. The N1pC/P60 proteins define a family of cell-wall peptidases that are widely represented in various bacterial lineages. Currently characterized members are known to hydrolyze D-γ-glutamyl-meso-diaminopimelate or N-acetylmuramate-L-alanine linkages. Detailed analysis of the N1pC/P60 peptidases showed that these proteins define a large superfamily encompassing several diverse groups of… CONTINUE READING
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