Evolutionary genomics of dog domestication

@article{Wayne2011EvolutionaryGO,
  title={Evolutionary genomics of dog domestication},
  author={Robert K. Wayne and Bridgett M. vonHoldt},
  journal={Mammalian Genome},
  year={2011},
  volume={23},
  pages={3-18}
}
We review the underlying principles and tools used in genomic studies of domestic dogs aimed at understanding the genetic changes that have occurred during domestication. We show that there are two principle modes of evolution within dogs. One primary mode that accounts for much of the remarkable diversity of dog breeds is the fixation of discrete mutations of large effect in individual lineages that are then crossed to various breed groupings. This transfer of mutations across the dog… 
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References

SHOWING 1-10 OF 106 REFERENCES
Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication
TLDR
It is shown that dog breeds share a higher proportion of multi-locus haplotypes unique to grey wolves from the Middle East, indicating that they are a dominant source of genetic diversity for dogs rather than wolves from east Asia, as suggested by mitochondrial DNA sequence data.
The canine genome.
TLDR
It is suggested that given these resources and the unique characteristics of breeds, that the dog is a uniquely valuable resource for studying the genetic basis of complex traits.
Canine Genomics and Genetics: Running with the Pack
TLDR
This review discusses the advances in mapping and sequencing that accelerated the field in recent years, then highlights findings of interest related to disease gene mapping and population structure, and summarizes novel results on the genetics of morphologic variation.
Genome sequence, comparative analysis and haplotype structure of the domestic dog
TLDR
A high-quality draft genome sequence of the domestic dog is reported, together with a dense map of single nucleotide polymorphisms (SNPs) across breeds, to shed light on the structure and evolution of genomes and genes.
Leading the way: canine models of genomics and disease
TLDR
This review highlights the unique features of the dog, such as population diversity and breed structure, that make it particularly amenable to genetic studies, and discusses two approaches for localizing disease genes in the dog.
Tracking footprints of artificial selection in the dog genome
  • J. Akey, A. Ruhe, +5 authors M. Neff
  • Biology, Medicine
    Proceedings of the National Academy of Sciences
  • 2010
TLDR
A genome-wide scan for selection in 275 dogs from 10 phenotypically diverse breeds that were genotyped for over 21,000 autosomal SNPs is described and 155 genomic regions that possess strong signatures of recent selection and contain candidate genes for phenotypes that vary most conspicuously among breeds are identified.
A genome-wide perspective on the evolutionary history of enigmatic wolf-like canids.
TLDR
It is found that these enigmatic canids are highly admixed varieties derived from gray wolves and coyotes, respectively, and divergent genomic history suggests that they do not have a shared recent ancestry as proposed by previous researchers.
Genes of domestic mammals augmented by backcrossing with wild ancestors.
TLDR
It is demonstrated that the numerous MHC DRB alleles that are present in modern domestic mammals implies that substantial backcrossing with wild ancestors, either accidental or intentional, has been important in shaping the genetic diversity of the authors' domesticates.
Localization of Canine Brachycephaly Using an Across Breed Mapping Approach
TLDR
Across breed mapping approach using a moderately dense SNP array, a low number of animals and breeds carefully selected for the phenotypes of interest to identify genetic variants responsible for breed-defining characteristics demonstrates that non-segregating traits under strong selection are equally tractable to genetic analysis using small sample numbers.
Lessons learned from the dog genome.
TLDR
The dog is finally emerging as a novel resource for studying the genetic basis of complex traits, including behavior, according to genome-wide association and selective sweep scans.
...
1
2
3
4
5
...